bcl-1, t(11;14), and mantle cell-derived lymphomas.
نویسندگان
چکیده
منابع مشابه
Direct visualization of dispersed 11q13 chromosomal translocations in mantle cell lymphoma by multicolor DNA fiber fluorescence in situ hybridization.
Several hematologic malignancies are associated with specific chromosomal translocations. Because of the dispersed distribution, chromosomal breakpoints may be difficult to detect using molecular techniques. We present a new application of a recently developed method, DNA fiber fluorescence in situ hybridization (fiber FISH), which allows direct visualization and mapping of chromosomal breakpoi...
متن کاملA subset of CD5- diffuse large B-cell lymphomas expresses nuclear cyclin D1 with aberrations at the CCND1 locus.
In 231 diffuse large B-cell lymphomas, the expression of cyclin D1 and CD5 was evaluated. All cases were CD5-. Ten (4.3%) were positive for cyclin D1 and were subjected to fluorescence in situ hybridization at the CCND1 locus. One case showed the t(11;14). In another case, the telomeric probe signal for cyclin D1 was lost in most tumor cells, and in a small proportion of the cells, there were f...
متن کاملMultiple breakpoints within the BCL-1 locus in B-cell lymphoma: rearrangements of the cyclin D1 gene.
Centrocytic lymphoma (CC) and intermediately differentiated lymphocytic lymphoma (IDL) are B-cell non-Hodgkin's lymphomas composed of lymphocytes presumably derived from follicle mantle cells. In these lymphomas, a specific chromosomal translocation, t(11;14)(q13;q32), has been described. Previous studies suggested an association between t(11;14) chromosomal translocations and BCL-1 rearrangeme...
متن کاملCentrocytic Lymphoma and Intermediate Lymphocytic Lymphoma: Identical Neoplasms Derived from Follicular Mantle Cells
HE t(11;14)(q13;q32) translocation and its molecular T counterpart, bcl-1 rearrangement, were originally reported as recurring cytogenetic and molecular genetic abnormalities in the lymphoproliferative diseases in 1979 and 1984, respectively.'*2 Although sporadic reports of these abnormalities continued to appear in the literature, particularly in the lymphocytic lymphomas and leukemias, no con...
متن کاملBCL-1 rearrangements and p53 mutations in atypical chronic lymphocytic leukemia with t(11;14)(q13;q32).
BACKGROUND AND OBJECTIVES The translocation t(11;14) (q13;q32), typically described in mantle cell lymphomas (MCL), has also been found in some cases of non-MCL lymphoproliferative disorders, such as splenic lymphoma with villous lymphocytes (SLVL), multiple myeloma (MM), prolymphocytic leukemia (PLL), typical and atypical chronic lymphocytic leukemia (CLL and aCLL). In order to define better t...
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عنوان ژورنال:
- Blood
دوره 78 2 شماره
صفحات -
تاریخ انتشار 1991